Monday, August 19, 2019
Home >> Neurobiology Research Centre (NRC) >> Molecular Genetics Laboratory Officer Charge Prof Sanjeev Jain

Molecular Genetics Laboratory (Officer In-charge: Prof. Sanjeev Jain)

The Molecular Genetics laboratory has been involved in several research projects in neuropsychiatric disorders including schizophrenia, bipolar disorder, autism, dementia, OCD and addiction. These studies have utilised different genetic methods such as case control association studies, linkage studies and next generation sequencing methods to understand the biology of these illnesses. As part of this, clinical endophenotypes such as treatment response, disease severity and co morbidities have been evaluated with a genetic perspective.  ‘Disease in a dish’ models have been initiated to study cellular endophenotypes in patient derived lines. Epigenetic studies are ongoing to understand the role of DNA methylation in alcohol addiction, stress and psychiatric illness. Another interest of the lab is to study the genetic epidemiology of triplet repeat disorders such as Huntington’s Disease as well as spinocerebellar ataxias such as SCA1, 2 &3.


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Workshops & Symposia conducted by the lab:


An international  conference cum workshop  on  “Epigenetics in Health and Disease"   was held from 22-24th January 2019 at NIMHANS in collaboration with the University of Exeter.


  1. P. Thirunavukkarasu, A. A. Vijayakumari, J. P. John, H. N. Halahalli, P. Paul, S. Sen, M. Purushottam, and S. Jain, “An exploratory association study of the influence of dysbindin and neuregulin polymorphisms on brain morphometry in patients with schizophrenia and healthy subjects from South India,” Asian Journal of Psychiatry. doi:10.1016/j.ajp.2014.04.002.

  1. LN. Kota, S. Bharath, M. Purushottam, P. Paul, P. T. Sivakumar, M. Varghese, and S. Jain, “Reduced telomere length in subjects with dementia and diabetes mellitus type 2 is independent of Apolipoprotein E4 genotype,” Asian Journal of Psychiatry,

doi:10.1016/j.ajp.2014.06.012. (In press).

  1. B. S. Bagepally, J. P. John, M. Varghese, H. N. Halahalli, L. Kota, P. T. Sivakumar, S. Bharath, and S. Jain, “Relationship of clinical and cognitive variables with brain morphometric abnormalities in Alzheimer’s disease: a voxel based morphometric study using 3-tesla MRI,” Aging Dis, vol. 4, no. 5, pp. 235–243, 2013.

  1. K. S. Bhalsing, V. Sowmya, M. Netravathi, S. Jain, and P. K. Pal, “Spinocerebellar Ataxia (SCA) type 2 presenting with chorea,” Parkinsonism Relat. Disord., vol. 19, no. 12, pp. 1171–1172%